HRID1664258

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10931

3,3-Dimethylacrylic acid

C5H8O2

HCID2758875

Trifluoromethanesulfonate

CF3O3S-

2 次

$结构：C=CCC/C(C)=C\C(=O)O$

HCID13947388

未命名化合物

结构：COc1ccc(CN2C(=O)SC[C@H]2[C@@]2(OC)C[C@@H](O)C[C@@H](CCc3ccccc3)O2)cc1

HCID59644071

未命名化合物

结构：C=CCCC[C@@H]1C[C@H](O)C[C@](OC)([C@@H]2CSC(=O)N2Cc2ccc(OC)cc2)O1

HCID59644085

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CN2C(=O)SC[C@H]2[C@@]2(OC)C[C@H](OC(=O)C=C(C)C)C[C@@H](CCc3ccccc3)O2)cc1

HCID59644063

未命名化合物

PROCEDURE

实验过程

Triflate formation using the method shown in Example 22, with the modification that (R)-4-((2R,4S,6R)-4-hydroxy-2-methoxy-6-phenethyl-tetrahydro-2H-pyran-2-yl)-3-(4-methoxybenzyl)thiazolidin-2-one is substituted for (R)-4-((2R,4S,6R)-4-hydroxy-2-methoxy-6-(pent-4-enyl)-tetrahydro-2H-pyran-2-yl)-3-(4-methoxybenzyl)thiazolidin-2-one, followed by triflate displacement using the method shown in Example 23, with the modification that 3-methyl-2-butenoic acid is substituted for (Z)-3-methylhepta-2,6-dienoic acid, affords the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6afe975191f7442481fdd181e96afb39
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08039465B2
来源说明: uspto-grants-2011_10

反应 SMILES

[O-]S(C(F)(F)F)(=O)=O.[OH:9][C@H:10]1[CH2:15][C@@H:14]([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[O:13][C@:12]([C@@H:26]2[CH2:30][S:29][C:28](=[O:31])[N:27]2[CH2:32][C:33]2[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=2)([O:24][CH3:25])[CH2:11]1.O[C@H]1C[C@@H](CCCC=C)O[C@]([C@@H]2CSC(=O)N2CC2C=CC(OC)=CC=2)(OC)C1.[CH3:70][C:71]([CH3:76])=[CH:72][C:73](O)=[O:74].C/C(/CCC=C)=C/C(O)=O>>[CH3:70][C:71]([CH3:76])=[CH:72][C:73]([O:9][C@@H:10]1[CH2:15][C@@H:14]([CH2:16][CH2:17][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[O:13][C@@:12]([O:24][CH3:25])([C@@H:26]2[CH2:30][S:29][C:28](=[O:31])[N:27]2[CH2:32][C:33]2[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=2)[CH2:11]1)=[O:74]