(R)-4-((1R,4Z,8Z,13R,15R)-15-methoxy-5-methyl-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadeca-4,8-dien-15-yl)-3-(4-methoxybenzyl)thiazolidin-2-one → (R)-4-((1R,13R,15R,Z)-15-Hydroxy-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadec-8-en-15-yl)thiazolidin-2-one

Participants

Role	Name	HCID	Charge
Reactant	(R)-4-((1R,4Z,8Z,13R,15R)-15-methoxy-5-methyl-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadeca-4,8-dien-15-yl)-3-(4-methoxybenzyl)thiazolidin-2-one	HCID 59644077	—
Reactant	(R)-4-((1R,13R,15R,Z)-15-methoxy-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadec-8-en-15-yl)-3-(4-methoxybenzyl)thiazolidin-2-one	HCID 59644082	—
Product	(R)-4-((1R,13R,15R,Z)-15-Hydroxy-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadec-8-en-15-yl)thiazolidin-2-one	HCID 24888493	—

Reaction Steps

Application of the method shown in Example 46, with the modification that (R)-4-((1R,13R,15R,Z)-15-methoxy-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadec-8-en-15-yl)-3-(4-methoxybenzyl)thiazolidin-2-one was substituted for (R)-4-((1R,4Z,8Z,13R,15R)-15-methoxy-5-methyl-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadeca-4,8-dien-15-yl)-3-(4-methoxybenzyl)thiazolidin-2-one, afforded the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08039465B2
Source dataset	uspto-grants-2011_10
ORD ID	ord-3e9ef141e07f4e8f9ce5b7bffbda27e5
Source note	uspto-grants-2011_10