HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-4-((1R,4Z,8Z,13R,15R)-15-methoxy-5-methyl-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadeca-4,8-dien-15-yl)-3-(4-methoxybenzyl)thiazolidin-2-one → HCID 24888490, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-4-((1R,4Z,8Z,13R,15R)-15-methoxy-5-methyl-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadeca-4,8-dien-15-yl)-3-(4-methoxybenzyl)thiazolidin-2-one | HCID 59644077 | — |
| Reactant | HCID 86641949 | HCID 86641949 | — |
| Product | HCID 24888490 | HCID 24888490 | — |
Reaction Steps
Application of the method shown in Example 46, with the modification that (1R,4Z,8Z,13R,15R)-15-methoxy-15-(((R)-3-(4-methoxybenzyl)-2-oxothiazolidin-4-yl)-5-methyl-14-oxa-2-aza-bicyclo[11.3.1]heptadeca-4,8-dien-3-one was substituted for (R)-4-((1R,4Z,8Z,13R,15R)-15-methoxy-5-methyl-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadeca-4,8-dien-15-yl)-3-(4-methoxybenzyl)thiazolidin-2-one, afforded the title compound, together with the 8E-isomer.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039465B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-3f75da4048074f7fb1e1040c966631d5 |
| Source note | uspto-grants-2011_10 |