Sodium borohydride → HCID 57969111, compound

HRID 1664449Notes

Reaction equation

HRID 1664449 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[O:12][C:13]1[CH:18]=[CH:17][C:16]([B:19]2OC(C)(C)C(C)(C)[O:20]2)=[C:15]([CH:28]=[O:29])[CH:14]=1)[C:5]([O:7][CH3:8])=[O:6].[BH4-].[Na+]>CO>[OH:20][B:19]1[C:16]2[CH:17]=[CH:18][C:13]([O:12][C:11]3[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=3[F:1])=[CH:14][C:15]=2[CH2:28][O:29]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 57969171HCID 57969171, compound

Product 1

HCID 57969111HCID 57969111, compoundYield 55.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methyl 3-fluoro-4-(3-formyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)benzoate (5 g, 12.5 mmol) in MeOH (125 mL) was added NaBH4 (709 mg; 18.75 mmol) in portions under N2 at 0° C. in an ice-bath. The reaction was stirred at 0° C. to room temperature. The reaction was monitored with TLC and was completed overnight. The mixture was cooled to rt. Solvent was evaporated to half volume via Rota vapor. The mixture was then cooled to 0° C., and quenched by adding water (12 mL) following by adding 6 N HCl (12 mL). Stirred at rt for 30 min, white Solid precipitated out. Filtered. The solid was gummy. The solid was suspended in water, sonicated for 1 hr. Filtered, washed with more water. Filtered, dried to get white solid. D139 (2.1 g). Yield 55.7%. M.p. 149-152° C. MS (ESI): m/z=303 (M+1, positive) and 301 (M−1, negative). HPLC (220 nm): 97.27% purity. (254 nM): 97.29% purity 1H NMR (DMSO-d6, 300 MHz): δ=9.19 (s, 1H), 7.88 (dd, J=1.8, 11.1 Hz, 1H), 7.80 (d, J=8.4 Hz, 1H), 7.75 (d, J=8.1 Hz, 1H), 7.21 (d, J=8.4 Hz, 1H), 7.07 (d, J=8.4 Hz, 2H), 4.93 (s, 2H), and 3.84 (s, 3H).

Workup

  1. customSolvent was evaporated to half volume via Rota vapor
  2. temperatureThe mixture was then cooled to 0° C.
  3. customquenched
  4. additionby adding water (12 mL)
  5. additionby adding 6 N HCl (12 mL)
  6. stirringStirred at rt for 30 min
  7. customwhite Solid precipitated out
  8. filtrationFiltered
  9. customsonicated for 1 hr
  10. filtrationFiltered
  11. washwashed with more water
  12. filtrationFiltered
  13. customdried
  14. customto get white solid

Sources & evidence

ORD record
ord-8d996f19492244d49ace04b7956cc4ba
Source dataset
uspto-grants-2011_10
Patent number
US08039450B2

Reaction notes

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