Sodium Hydroxide → HCID 67358360, compound

Participants

Reaction Steps

A stirred solution of crude ethyl (±)-(3-dibenzylcarbamoyl-1,2,3,4-tetrahydro-carbazol-9-yl)-acetate (0.1 mmol) in THF (1 ml) is treated with 0.2 N aqueous NaOH (0.5 ml, 0.1 mmol) added at rt for 15 min. Then, the reaction mixture is extracted twice with diethyl ether (2 ml), acidified to pH 1 by addition of 1M HCl and extracted with CH2Cl2. The combined organic layers are dried (Na2SO4), filtered and evaporated. The resulting solid is recrystallized from diethyl ether to yield title compound as a pale yellow solid. tR (LC-2) 2.74 min; MS (positive ion) m/z 453.26 [M+H]+ (calcd 452.55 for C29H28N2O3).

Provenance & Evidence