Hydrazine → HCID 178446162, compound

HRID 1664505Notes

Reaction equation

HRID 1664505 reaction equation
CS[CH:3]1[N:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:10]2[N:9]=[C:8]([C:17]([F:20])([F:19])[F:18])[NH:7][C:6]=2[C:5](=[O:21])[NH:4]1.[NH2:22][NH2:23]>O>[CH2:12]([N:11]1[C:10]2[N:9]=[C:8]([C:17]([F:20])([F:19])[F:18])[NH:7][C:6]=2[C:5](=[O:21])[NH:4]/[C:3]/1=[N:22]\[NH2:23])[CH2:13][CH2:14][CH2:15][CH3:16]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 667258292-(methylthio)-3-pentyl-8-(trifluoromethyl)-1,2,3,7-tetrahydro-6H-purin-6-one

Product 1

HCID 178446162HCID 178446162, compoundYield 86.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2-(methylthio)-3-pentyl-8-(trifluoromethyl)-1,2,3,7-tetrahydro-6H-purin-6-one (0.61 g, 0.95 mmol), hydrazine (3 mL, 100 mmol) and water (3 mL) was stirred at 100° C. for 1 h. The reaction solution was concentrated under reduced pressure. The residue was dissolved in DMSO and purified by preparative LCMS. The product fractions were collected and lyophilized to give the desired product (0.25 g, 65%). LCMS calculated for C11H15F3N6O: (M+H) 305.1. found 305.1.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. dissolutionThe residue was dissolved in DMSO
  3. custompurified by preparative LCMS
  4. customThe product fractions were collected

Sources & evidence

ORD record
ord-c5403411e432421e871174ec1308c02d
Source dataset
uspto-grants-2011_10
Patent number
US08039478B2

Reaction notes

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