反应详情

The mixture of 9-butyl-3-(chloromethyl)-6,9-dihydro-5h-[1,2,4]triazolo[4,3-a]purin-5-one (35 mg, 125 mmol) in 4 M of sodium methoxide in methanol (0.5 mL, 2 mmol) was stirred at room temperature overnight. The reaction mixture was diluted with water and extracted with ethyl acetate three times. The combined organic layers was dried with sodium sulfate, filtered, and concentrated in vacuo to yield the desired product (6 mg, 17.42%). LCMS calculated for C13H19N6O2 (M+H): 290.2. found 290.2.

1. extractionextracted with ethyl acetate three times
2. dry with materialThe combined organic layers was dried with sodium sulfate
3. filtrationfiltered
4. concentrationconcentrated in vacuo