HCID 178446146, compound → 3-(3-bromobenzyl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one

HRID 1664546Notes

Reaction equation

HRID 1664546 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([NH:11]/[N:12]=[C:13]2\[NH:14][C:15](=[O:27])[C:16]3[NH:17][CH:18]=[N:19][C:20]=3[N:21]\2[CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=O)[CH:5]=[CH:6][CH:7]=1>C1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[CH2:8][C:9]1[N:14]2[C:15](=[O:27])[C:16]3[NH:17][CH:18]=[N:19][C:20]=3[N:21]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:13]2=[N:12][N:11]=1

Participants

3

Reactant 1

HCID 178446146HCID 178446146, compound

Product 1

HCID 576001603-(3-bromobenzyl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-oneYield 86%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The mixture of 2-(3-bromophenyl)-N′-[(2E)-6-oxo-3-pentyl-1,3,6,7-tetrahydro-2H-purin-2-ylidene]acetohydrazide (1.8 g, 4.2 mmol) in benzene (100 mL) was refluxed overnight. The reaction mixture was concentrated to give the desired product 1.5 g. LCMS calculated for C18H20BrN6O (M+H): 415.1. found: 415.1.

Workup

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-b3422c0205924777b77a1c38cff31961
Source dataset
uspto-grants-2011_10
Patent number
US08039478B2

Reaction notes

Loading…