HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1664552Generated: October 29, 2026
N-bromobutanimide → 6-bromo-4-pentyl-4,7-dihydro-8H-tetrazolo[1,5-a]purin-8-one
https://huagongshe.com/reaction/1664552
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4-pentyl-4,7-dihydro-8H-tetrazolo[1,5-a]purin-8-one | HCID 57600297 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-bromo-4-pentyl-4,7-dihydro-8H-tetrazolo[1,5-a]purin-8-one | HCID 25059654 | 13.8% |
Reaction Steps
The mixture of 4-pentyl-4,7-dihydro-8H-tetrazolo[1,5-a]purin-8-one (94.6 mg, 0.38 mmol) and NBS (75 mg, 0.42 mmol) in THF (20 ml) was stirred at 70° C. for 1 hour. After evaporation of solvent, the residue was purified by preparative LC-MS to yield the desired product (17.1 mg, 13.7%). LCMS calculated for C10H13BrN7O (M+H): 326.0. found: 326.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08039478B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-8d0624b442ff46aca43c7c4f626d3f76 |
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| Source note | uspto-grants-2011_10 |
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