HCID 178446142, compound → 3-(5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)propanoic acid

HRID 1664554Notes

Reaction equation

HRID 1664554 reaction equation
[O:1]=[C:2]1[NH:10]/[C:9](=[N:11]\[N:12]=[CH:13]\[CH2:14][CH2:15][C:16]([OH:18])=[O:17])/[N:8]([CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[C:7]2[N:6]=[CH:5][NH:4][C:3]1=2>C(O)(=O)C>[O:1]=[C:2]1[N:10]2[C:13]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[N:12][N:11]=[C:9]2[N:8]([CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[C:7]2[N:6]=[CH:5][NH:4][C:3]1=2

Participants

3

Reactant 1

HCID 178446142HCID 178446142, compound

Product 1

HCID 576003033-(5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)propanoic acidYield 99%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The mixture of (4E)-4-[(2E)-(6-oxo-3-pentyl-1,3,6,7-tetrahydro-2H-purin-2-ylidene)hydrazono]butanoic acid (1.367 g, 5.1 mmol) in acetic acid (70 ml) was refluxed for 1 hour. Evaporation of solvent afforded the desired product (1.29 g, 99%) as yellowish solid. LCMS calculated for C14H19N6O3 (M+H): 319.2. found: 319.2.

Workup

  1. temperaturewas refluxed for 1 hour
  2. customEvaporation of solvent

Sources & evidence

ORD record
ord-32bcc7afc7764c6f938c668770db1855
Source dataset
uspto-grants-2011_10
Patent number
US08039478B2

Reaction notes

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