HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1664555Generated: October 29, 2026
N-bromobutanimide → 3-(7-Bromo-5-oxo-9-pentyl-6,9-dihydro-5h-[1,2,4]triazolo[4,3-a]purin-3-yl)propanoic acid
https://huagongshe.com/reaction/1664555
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 3-(5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)propanoic acid | HCID 57600303 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(7-Bromo-5-oxo-9-pentyl-6,9-dihydro-5h-[1,2,4]triazolo[4,3-a]purin-3-yl)propanoic acid | HCID 25059656 | 23.7% |
Reaction Steps
The mixture of 3-(5-oxo-9-pentyl-6,9-dihydro-5H[1,2,4]triazolo[4,3-a]purin-3-yl)propanoic acid (203 mg, 0.64 mmole) and NBS (125.8 mg, 7.0 mmol) in THF (25 ml) was stirred at 70° C. for 2 hours. After evaporation of solvent, the residue was purified by preparative LC-MS to afford 60.2 mg (23.7%) of the desired product (60.2 mg, 23.7%) as white solid. LCMS calculated for C14H18BrN6O3 (M+H): 397.1. found: 371.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08039478B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-4d208e5f0a63470984175027602ef0d6 |
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| Source note | uspto-grants-2011_10 |
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