反应详情

To a solution of methyl 3-(3-benzyl-1,2,4-oxadiazol-5-yl)propanoate (5.2 g, 21.1 mmole) in methanol (30 ml) was added 50 ml of 1N NaOH. The mixture was stirred at room temperature for 2 hours. The mixture was adjusted to PH=3-4 under ice bath, and extracted with EtOAc (3×). The combined organic phases were washed with water and brine, dried over Na2SO4 and concentrated to yield the desired product (4.8 g, 98%) as colorless oil. LCMS calculated for C12H13N2O3 (M+H): 233.1. found 233.0.

1. extractionextracted with EtOAc (3×)
2. washThe combined organic phases were washed with water and brine
3. dry with materialdried over Na2SO4
4. concentrationconcentrated