反应详情

The mixture of 3-(3-benzyl-1,2,4-oxadiazol-5-yl)-N′-[(2E)-6-oxo-3-pentyl-8-(trifluoromethyl)-1,3,6,7-tetrahydro-2H-purin-2-ylidene]propanohydrazide (220.1 mg, 0.424 mmole) in toluene (20 ml) was refluxed for 5 hours. After evaporation of solvent, the residue was purified by preparative LCMS to yield the desired product (37.9 mg, 17.8%) as white solid. LCMS calculated for C23H24F3N8O2 (M+H): 501.2. found 501.1.

1. temperaturewas refluxed for 5 hours
2. customAfter evaporation of solvent
3. customthe residue was purified by preparative LCMS