HCID 178446157, compound → benzyl[(5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)methyl]carbamate

HRID 1664569Notes

Reaction equation

HRID 1664569 reaction equation
O=[C:2]([NH:15]/[N:16]=[C:17]1\[NH:18][C:19](=[O:31])[C:20]2[NH:21][CH:22]=[N:23][C:24]=2[N:25]\1[CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:3][NH:4][C:5](=[O:14])[O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C1(C)C=CC=CC=1>[CH2:7]([O:6][C:5](=[O:14])[NH:4][CH2:3][C:2]1[N:18]2[C:19](=[O:31])[C:20]3[NH:21][CH:22]=[N:23][C:24]=3[N:25]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[C:17]2=[N:16][N:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 1

HCID 178446157HCID 178446157, compound

Product 1

HCID 57600256benzyl[(5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)methyl]carbamateYield 87.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The solution of benzyl 2-oxo-2-[(2E)-2-(6-oxo-3-pentyl-1,3,6,7-tetrahydro-2H-purin-2-ylidene)hydrazino]ethylcarbamate (0.60 g, 0.84 mmol) in toluene (30 mL) was refluxed overnight. M+H=410.1. The product was precipitated from the reaction mixture and filtered to give the desired product (300 mg, 87%). LCMS calculated for C20H24N7O3 (M+H): 410.2. found: 410.2.

Workup

  1. customThe product was precipitated from the reaction mixture
  2. filtrationfiltered

Sources & evidence

ORD record
ord-869843fd5f7c497dbd2306ddc1309976
Source dataset
uspto-grants-2011_10
Patent number
US08039478B2

Reaction notes

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