HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1664577Generated: October 29, 2026
N-bromobutanimide → 2-bromo-4-pentyl-1,4-dihydro-9H-[1,2,4]triazolo[1,5-a]purin-9-one
https://huagongshe.com/reaction/1664577
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4-pentyl-1,4-dihydro-9H-[1,2,4]triazolo[1,5-a]purin-9-one | HCID 57600218 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-bromo-4-pentyl-1,4-dihydro-9H-[1,2,4]triazolo[1,5-a]purin-9-one | HCID 57600215 | 12.4% |
Reaction Steps
To the mixture of 4-pentyl-1,4-dihydro-9H-[1,2,4]triazolo[1,5-a]purin-9-one (19 mg, 0.077 mmol) in tetrahydrofuran (10 mL) was added N-bromosuccinimide (20 mg, 0.12 mol) at rt. The mixture was stirred at 70° C. for 1 hour. The mixture was concentrated and purified by preparative LCMS to yield the desired product (3.10 mg, 12.4%). LCMS calculated for C11H14BrN6O (M+H): 325.0. found: 325.0, 327.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08039478B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-e9110266b18b4d67b8dc26486c737b02 |
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| Source note | uspto-grants-2011_10 |
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