HCID 178446144, compound → HCID 57961335, compound

HRID 1664592Notes

Reaction equation

HRID 1664592 reaction equation
[O:1]=[C:2]1[NH:10]/[C:9](=[N:11]\[N:12]=[CH:13]/[CH2:14][CH2:15][NH:16][C:17](=[O:26])[O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)/[N:8]([CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[C:7]2[N:6]=[CH:5][NH:4][C:3]1=2>C(O)(=O)C>[CH2:19]([O:18][C:17](=[O:26])[NH:16][CH2:15][CH2:14][C:13]1[N:10]2[C:2](=[O:1])[C:3]3[NH:4][CH:5]=[N:6][C:7]=3[N:8]([CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[C:9]2=[N:11][N:12]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 1

HCID 178446144HCID 178446144, compound

Product 1

HCID 57961335HCID 57961335, compoundYield 54.8%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of benzyl (3Z)-3-[(2E)-(6-oxo-3-pentyl-1,3,6,7-tetrahydro-2H-purin-2-ylidene)hydrazono]propylcarbamate (4.0 g, 5.6 mmol) in acetic acid (50 mL) was refluxed in the air overnight. The mixture was concentrated and purified by preparative LCMS to give the desired product (1.3 g, 54% yield) as a white solid. LCMS calculated for C21H26N7O3 (M+H): 424.2. found: 424.2.

Workup

  1. temperaturewas refluxed in the air overnight
  2. concentrationThe mixture was concentrated
  3. custompurified by preparative LCMS

Sources & evidence

ORD record
ord-94cf7475d79f485db05fcd0323c96f6e
Source dataset
uspto-grants-2011_10
Patent number
US08039478B2

Reaction notes

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