HCID 57961335, compound → HCID 57600155, compound

HRID 1664593Notes

Reaction equation

HRID 1664593 reaction equation
C(OC(=O)[NH:10][CH2:11][CH2:12][C:13]1[N:17]2[C:18](=[O:30])[C:19]3[NH:20][CH:21]=[N:22][C:23]=3[N:24]([CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[C:16]2=[N:15][N:14]=1)C1C=CC=CC=1>CO.[Pd]>[NH2:10][CH2:11][CH2:12][C:13]1[N:17]2[C:18](=[O:30])[C:19]3[NH:20][CH:21]=[N:22][C:23]=3[N:24]([CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[C:16]2=[N:15][N:14]=1

Participants

4

Reactant 1

HCID 57961335HCID 57961335, compound

Product 1

HCID 57600155HCID 57600155, compoundYield 92.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of benzyl[2-(5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)ethyl]carbamate (0.52 g, 1.2 mmol) in methanol (50 mL) was added 10% Pd/C (100 mg). The reaction mixture was shaken in a hydrogenation reactor under 50 Psi H2 for 3 hours. The reaction mixture was filtered through a pad of celite. The filtrate was concentrated to give the desired product (320 mg, 90% yield). LCMS calculated for C13H20N7O (M+H): 290.2. found: 290.1.

Workup

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-094adf04100e4219bcc55f8c28587ce9
Source dataset
uspto-grants-2011_10
Patent number
US08039478B2

Reaction notes

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