Sodium Methoxide → HCID 67007225, compound

HRID 1664608Notes

Reaction equation

HRID 1664608 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@@H:2]1[C:10]([NH:12][CH2:13][C:14]([O:16]C)=O)=[O:11].C[O-].[Na+]>C(O)C>[C:10]1(=[O:11])[C@H:2]2[CH2:3][C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=3[N:1]2[C:14](=[O:16])[CH2:13][NH:12]1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 86595546HCID 86595546, compound

Product 1

HCID 67007225HCID 67007225, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

methyl {[(2R)-2,3-dihydro-1H-indol-2-ylcarbonyl]amino}acetate (390 mg) was mixed with 100 mg of NaOMe in 5 mL of Ethanol. The mixture was refluxed for 2 hours and cooled to RT. The crude material was purified by flash chromatography to give the desired (10aR)-2,3,10,10a-tetrahydropyrazino[1,2-a]indole-1,4-dione.

Workup

  1. temperatureThe mixture was refluxed for 2 hours
  2. customThe crude material was purified by flash chromatography

Sources & evidence

ORD record
ord-1fc7c8318ddf4e81820bcdbfe636b520
Source dataset
uspto-grants-2011_10
Patent number
US08039471B2

Reaction notes

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