Benzhydrol → Carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester benzhydryl ester

HRID 1664637Notes

Reaction equation

HRID 1664637 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](N1C=CN=C1)=[O:11])[CH2:2]2.[CH:17]([OH:30])([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH:17]([O:30][C:10](=[O:11])[O:9][C@@H:3]1[CH:4]2[CH2:5][CH2:6][N:1]([CH2:8][CH2:7]2)[CH2:2]1)([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 7037BenzhydrolHCID 59187189imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester

Product 1

HCID 66628315Carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester benzhydryl ester

Procedure

The desired product was prepared by reacting imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester with benzhydrol.

Sources & evidence

ORD record
ord-d2a9c2c96ce1443ba5802e4a7885f5ae
Source dataset
uspto-grants-2011_10
Patent number
US08039483B2

Reaction notes

Loading…