(1,1'-Biphenyl)-2-ol → Carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester biphenyl-2-yl ester

HRID 1664638Notes

Reaction equation

HRID 1664638 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](N1C=CN=C1)=[O:11])[CH2:2]2.[OH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[C:19]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[O:17][C:10](=[O:11])[O:9][C@@H:3]1[CH:4]2[CH2:5][CH2:6][N:1]([CH2:8][CH2:7]2)[CH2:2]1

Participants

3

Reactant 2

HCID 7017(1,1'-Biphenyl)-2-olHCID 59187189imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester

Product 1

HCID 59187171Carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester biphenyl-2-yl ester

Procedure

The desired product was prepared by reacting imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester with 2-hydroxy biphenyl.

Sources & evidence

ORD record
ord-ea5df60b750f4f5fb6c96e1992539735
Source dataset
uspto-grants-2011_10
Patent number
US08039483B2

Reaction notes

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