2-Thiophenemethanol → Carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester thiophen-2-ylmethyl ester

HRID 1664639Notes

Reaction equation

HRID 1664639 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](N1C=CN=C1)=[O:11])[CH2:2]2.[OH:17][CH2:18][C:19]1[S:20][CH:21]=[CH:22][CH:23]=1>>[S:20]1[CH:21]=[CH:22][CH:23]=[C:19]1[CH2:18][O:17][C:10](=[O:11])[O:9][C@@H:3]1[CH:4]2[CH2:5][CH2:6][N:1]([CH2:8][CH2:7]2)[CH2:2]1

Participants

3

Reactant 2

HCID 694672-ThiophenemethanolHCID 59187189imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester

Product 1

HCID 59187160Carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester thiophen-2-ylmethyl ester

Procedure

The desired product was prepared by reacting imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester with 2-hydroxy methyl thiophene.

Sources & evidence

ORD record
ord-55b628e61ce446699efd8e7c2a9ecce3
Source dataset
uspto-grants-2011_10
Patent number
US08039483B2

Reaction notes

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