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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1664649Generated: October 31, 2026

(3,4-Difluorophenyl)(phenyl)methanol → Carbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (3,4-difluoro-phenyl)-phenyl-methyl ester

https://huagongshe.com/reaction/1664649

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3,4-Difluorophenyl)(phenyl)methanolHCID 2758251—
Reactantimidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl esterHCID 59187189—
ProductCarbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (3,4-difluoro-phenyl)-phenyl-methyl esterHCID 86638976—

Reaction Steps

The desired product was prepared by reacting imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester with (3,4-difluoro-phenyl)-phenyl-methanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08039483B2
Source datasetuspto-grants-2011_10
ORD IDord-145a270c69fa4694937f3c27f337fffc
Source noteuspto-grants-2011_10