反应详情

温度

55 °C

To a solution of methyl [5-(benzyloxy)-3-oxo-2,3-dihydro-1H-inden-1-yl]acetate (1.0 g, 3.22 mmol) and 1-methylcyclohexa-1,4-diene (10 ml, 89 mmol) in ethanol (30 ml) was added 10% Pd/C (0.686 g, 0.644 mmol), and the mix was stirred at 55° C. After 1 hour the mix was filtered through a bed of Celite, washing with ethanol The filtrate was concentrated and the residue was concentrated from ether-hexane to give methyl (5-hydroxy-3-oxo-2,3-dihydro-1H-inden-1-yl)acetate. LC-MS for C12H12O4: calc 220, found 221 [M+H].

1. filtrationAfter 1 hour the mix was filtered through a bed of Celite
2. washwashing with ethanol The filtrate
3. concentrationwas concentrated
4. concentrationthe residue was concentrated from ether-hexane