反应详情

To detach the Boc protecting group, the compound from example 17 (580 mg, 1.83 mmol) was admixed with 10 ml of 1:1 TFA/DCM and stirred at RT for 30 min. Subsequently, the mixture was concentrated by evaporation under reduced pressure and subjected to azeotropic distillation with dichloromethane and toluene, and solvent residues were removed under high vacuum. The product was present as the trifluoroaceate.

1. concentrationSubsequently, the mixture was concentrated by evaporation under reduced pressure
2. distillationsubjected to azeotropic distillation with dichloromethane and toluene, and solvent residues
3. customwere removed under high vacuum