HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)quinolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Benzyl-4-(2-chloroquinolin-3-yl)piperidin-4-ol | HCID 18444248 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)quinolin-2(1H)-one | HCID 18444247 | — |
Reaction Steps
3-(1-Benzyl-4-hydroxypiperidin-4-yl)-2-chloroquinoline (11.0 g, 31.1 mmol) was refluxed in 6 N hydrochloric acid for 8 h. The solution was cooled and water (100 mL) added. The precipitated solid was collected and dried to give the title compound, 7.9 g. MS 317 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039460B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-7c9637653fc14cfbb736c4d04215cab3 |
| Source note | uspto-grants-2011_10 |