Hydrazine → Benzyl 4-(6-methyl-3-oxo-2,3,4,5-tetrahydropyridazine-4-yl)piperidine-1-carboxylate

HRID 1664780Notes

Reaction equation

[NH2:1][NH2:2].C([O:5][C:6]([CH:8]([CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:20])[CH2:15][CH2:14]1)[CH2:9][C:10](=O)[CH3:11])=O)C>C(O)(=O)C>[CH3:11][C:10]1[CH2:9][CH:8]([CH:13]2[CH2:18][CH2:17][N:16]([C:19]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[O:20])[CH2:15][CH2:14]2)[C:6](=[O:5])[NH:1][N:2]=1

Participants

Conditions

Temperature: 50 °C

Procedure

Hydrazine (4.72 mL, 148.7 mmol) was added to a solution of benzyl 4-[1-(ethoxycarbonyl)-3-oxobutyl]piperidine-1-carboxylate (2.69 g, 7.44 mmol) in acetic acid (110 mL). The reaction mixture was heated at 50° C. After 1 h, the reaction mixture was concentrated. The residue was diluted with dichloromethane, neutralized by saturated aqueous sodium bicarbonate. The mixture was extracted with dichloromethane (3×), and the combined organic extracts were dried over magnesium sulfate and concentrated to give the title compound. MS 330.2 (M+1).

Workup

concentrationthe reaction mixture was concentrated
additionThe residue was diluted with dichloromethane
extractionThe mixture was extracted with dichloromethane (3×)
dry with materialthe combined organic extracts were dried over magnesium sulfate
concentrationconcentrated

Sources & evidence

ORD record: ord-c29e158e98c84ad5aa6f438638272007
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08039460B2

Reaction notes

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