反应详情

温度

50 °C

Hydrazine (4.72 mL, 148.7 mmol) was added to a solution of benzyl 4-[1-(ethoxycarbonyl)-3-oxobutyl]piperidine-1-carboxylate (2.69 g, 7.44 mmol) in acetic acid (110 mL). The reaction mixture was heated at 50° C. After 1 h, the reaction mixture was concentrated. The residue was diluted with dichloromethane, neutralized by saturated aqueous sodium bicarbonate. The mixture was extracted with dichloromethane (3×), and the combined organic extracts were dried over magnesium sulfate and concentrated to give the title compound. MS 330.2 (M+1).

1. concentrationthe reaction mixture was concentrated
2. additionThe residue was diluted with dichloromethane
3. extractionThe mixture was extracted with dichloromethane (3×)
4. dry with materialthe combined organic extracts were dried over magnesium sulfate
5. concentrationconcentrated