反应详情

Palladium (10% on carbon; 0.70 g) was added to a solution of benzyl 4-(6-methyl-3-oxo-2,3-dihydropyridazin-4-yl)piperidine-1-carboxylate (1.45 g, 4.43 mmol) in ethanol (100 mL). The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (1 atm). After 24 h, the mixture was filtered through celite and concentrated to give the title compound (0.86 g). MS 194.1 (M+1).

1. customThe reaction vessel was evacuated
2. additionback-filled with nitrogen (3×)
3. additionback-filled with hydrogen (1 atm)
4. filtrationthe mixture was filtered through celite and
5. concentrationconcentrated