HCID 67438530, compound → HCID 59722662, compound

HRID 1664782Notes

Reaction equation

HRID 1664782 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:14][CH2:13][N:12](C(OCC3C=CC=CC=3)=O)[CH2:11][CH2:10]2)[C:5](=[O:8])[NH:6][N:7]=1>C(O)C.[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[C:5](=[O:8])[NH:6][N:7]=1

Participants

4

Reactant 1

HCID 67438530HCID 67438530, compound

Product 1

HCID 59722662HCID 59722662, compoundYield 100.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Palladium (10% on carbon; 0.70 g) was added to a solution of benzyl 4-(6-methyl-3-oxo-2,3-dihydropyridazin-4-yl)piperidine-1-carboxylate (1.45 g, 4.43 mmol) in ethanol (100 mL). The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (1 atm). After 24 h, the mixture was filtered through celite and concentrated to give the title compound (0.86 g). MS 194.1 (M+1).

Workup

  1. customThe reaction vessel was evacuated
  2. additionback-filled with nitrogen (3×)
  3. additionback-filled with hydrogen (1 atm)
  4. filtrationthe mixture was filtered through celite and
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-7fbbdfa362a646ee968296990601ae96
Source dataset
uspto-grants-2011_10
Patent number
US08039460B2

Reaction notes

Loading…