HCID 67439310, compound → Benzyl 4-(6-cyclopropyl-3-oxo-2,3-dihydropyridazin-4-yl)piperidine-1-carboxylate

Participants

Reaction Conditions

Reaction Steps

Copper(II) chloride (anhydrous; 101 mg, 0.75 mmol) was added to a solution of benzyl 4-(6-cyclopropyl-3-oxo-2,3,4,5-tetrahydropyridazine-4-yl)piperidine-1-carboxylate (134 mg, 0.38 mmol) in acetonitrile (16 mL). The reaction mixture was heated to 90° C. After 18 h, the mixture was cooled to ambient temperature and concentrated. Dichloromethane was added to the concentrated mixture, followed by hydrochloric acid (1 N in water). The mixture was extracted with dichloromethane (3×) and the combined organic extracts were dried over magnesium sulfate and concentrated. Purification by silica gel chromatography (100% dichloromethane→90% dichloromethane/methanol) gave the title compound (54 mg). MS 354.1 (M+1).

Provenance & Evidence