Lawesson's reagent → HCID 59722608, compound

Participants

Reaction Conditions

Reaction Steps

Lawesson's reagent [2,4-Bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide] (140 mg, 0.35 mmol) was added to a suspension of tert-butyl [(3R,6S)-6-cyclohexyl-2-oxoazepan-3-yl]carbamate (210 mg, 0.68 mmol) in toluene (8 mL) and the mixture was heated to 90° C. After 1 h, the reaction was allowed to cool to ambient temperature and concentrated. Purification by silica gel chromatography (100% dichloromethane→95% dichloromethane/ethyl acetate) gave the title compound (132 mg). MS 327.2 (M+1).

Provenance & Evidence