HCID 67439536, compound → HCID 67440237, compound

Participants

Reaction Steps

Raney-Nickel (2800, slurry in water; washed with ethyl alcohol (3×); 3.8 g) was added to a solution of ethyl 5-cyano-5-(2,3-difluorophenyl)pentanoate (4.75 g, 17.8 mmol) in ethanol (100 mL). Ammonia gas was bubbled to the reaction mixture and the mixture was stirred under hydrogen at 48 psi. After 18 h, the reaction was filtered and concentrated. MS 272.1 (M+1).

Provenance & Evidence