Cornforth reagent → HCID 59722632, compound

HRID 1664836Notes

Reaction equation

HRID 1664836 reaction equation
[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.[F:22][C:23]1[C:28]([F:29])=[CH:27][CH:26]=[CH:25][C:24]=1[C@H:30]1[CH2:36][NH:35][C:34](=[N:37][CH2:38][CH:39](O)[CH2:40][C:41]([F:44])([F:43])[F:42])[C@H:33]([NH:46][C:47](=[O:53])[O:48][C:49]([CH3:52])([CH3:51])[CH3:50])[CH2:32][CH2:31]1>C(#N)C>[F:22][C:23]1[C:28]([F:29])=[CH:27][CH:26]=[CH:25][C:24]=1[C@H:30]1[CH2:36][N:35]2[C:39]([CH2:40][C:41]([F:44])([F:43])[F:42])=[CH:38][N:37]=[C:34]2[C@H:33]([NH:46][C:47](=[O:53])[O:48][C:49]([CH3:52])([CH3:51])[CH3:50])[CH2:32][CH2:31]1

Participants

4

Reactant 2

HCID 2724130Cornforth reagentHCID 178453871HCID 178453871, compound

Product 1

HCID 59722632HCID 59722632, compoundYield 75.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Pyridinium dichromate (7.92 g, 21.0 mmol) was added to a solution of crude tert-butyl {(3R,6S)-6-(2,3-difluorophenyl)-2-[(4,4,4-trifluoro-2-hydroxybutyl)imino]azepan-3-yl}carbamate (3.27 g, 7.01 mmol) in acetonitrile (70 mL). After 70 h, the mixture was filtered and concentrated. Saturated aqueous sodium bicarbonate was added and the mixture was extracted with dichloromethane (3×). The combined organic extracts were dried over magnesium sulfate, filtered, and concentrated. Purification by silica gel chromatography (100% dichloromethane→96% dichloromethane/methanol) gave the title compound (2.35 g). MS 446.1 (M+1). 1H NMR (500 MHz, CDCl3) δ 7.14-7.09 (m, 1H), 6.97-6.94 (m, 2H), 6.33 (d, J=5.8 Hz, 1H), 4.82 (dd, J=10.0, 3.9 Hz, 1H), 4.12-4.07 (m, 1H), 3.99 (d, J=14.6 Hz, 1H), 3.37 (q, J=20.0, 10.0 Hz, 2H), 2.94 (t, J=110.2 Hz, 1H), 2.44 (d, J=13.7 Hz, 1H), 2.34-2.26 (m, 1H), 2.16-2.13 (m, 1H), 1.63-1.60 (m, 1H), 1.57 (s, 9H).

Workup

  1. filtrationthe mixture was filtered
  2. concentrationconcentrated
  3. additionSaturated aqueous sodium bicarbonate was added
  4. extractionthe mixture was extracted with dichloromethane (3×)
  5. dry with materialThe combined organic extracts were dried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customPurification by silica gel chromatography (100% dichloromethane→96% dichloromethane/methanol)

Sources & evidence

ORD record
ord-45313aa373dc4da5a8bfa44abd76540c
Source dataset
uspto-grants-2011_10
Patent number
US08039460B2

Reaction notes

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