Potassium sodium tartarate → HCID 59722595, compound

Participants

Reaction Steps

Diisobutylaluminum hydride (1.0 M in hexanes; 3.77 mL, 3.77 mmol) was added to a solution of methyl [(6S,9R)-9-[(tert-butoxycarbonyl)amino]-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-3-yl]acetate (328 mg, 0.75 mmol) in dichloromethane (12 mL) at 0° C. After 1 h, saturated aqueous potassium sodium tartrate was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate, filtered and concentrated. Purification by silica gel chromatography (100% dichloromethane→94% dichloromethane/methanol) gave the title compound (218 mg). MS 408.1 (M+1).

Provenance & Evidence