Acetic Acid → HCID 59722620, compound

Participants

Reaction Steps

Sodium cyanoborohydride (12 mg, 0.185 mmol) was added to a solution of tert-butyl (6S,9R)-6-(2,3-difluorophenyl)-3-(2-oxoethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate (50 mg, 0.123 mmol) and dimethylamine (2.0 M in tetrahydrofuran; 0.185 mL, 0.370 mmol) in methanol (5 mL) adjusted to pH 5 with acetic acid. After 2 h, the solution was concentrated. Purification by silica gel chromatography (100% dichloromethane→92% dichloromethane/methanol) gave the title compound (45 mg). MS 435.2 (M+1).

Provenance & Evidence