HCID 59722730, compound → HCID 59722677, compound

Participants

Reaction Steps

Methylmagnesium bromide (3.0 M in ether; 0.33 mL, 1.0 mmol) was added to a solution of tert-butyl (6S,9R)-6-(2,3-difluorophenyl)-3-formyl-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate (130 mg, 0.33 mmol) in tetrahydrofuran (3 mL) at 0° C. After 10 min, the reaction was quenched with water and the mixture was extracted with dichloromethane (3×). The organic layer was washed with water, saturated brine, dried over magnesium sulfate, filtered and concentrated. MS 408.1 (M+1).

Provenance & Evidence