2-Methyl-2-butene → HCID 67439630, compound

Participants

Reaction Steps

Sodium dihydrogen phosphate (127 mg, 0.92 mmol) and sodium chlorite (42 mg, 0.46 mmol) were added to a solution of tert-butyl (6S,9R)-6-(2,3-difluorophenyl)-3-formyl-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate (45 mg, 0.12 mmol) in tetrahydrofuran (0.8 mL), water (0.8 mL), tert-butanol (0.2 mL), and 2-methyl-2-butene (0.2 mL). After 3 h of vigorously stirring, the reaction mixture was quenched with saturated solution of ammonium chloride. The mixture was extracted with ethyl acetate (3×), and the combined organic extracts were washed with water, saturated brine, dried over sodium sulfate, filtered and concentrated. MS 408.1 (M+1).

Provenance & Evidence