Tetrahydrofuran → HCID 59722653, compound

Participants

Reaction Steps

Ethylmagnesium bromide (3.0 M in ether; 82.0 μL, 0.247 mmol) was added to a solution of tert-butyl (6S,9R)-3-acetyl-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate (25 mg, 0.062 mmol) in tetrahydrofuran (1 mL) at 0° C. After 10 min, the reaction mixture was quenched with water and the mixture was extracted with dichloromethane (3×). The organic layer was washed with water, saturated brine, dried over magnesium sulfate, filtered and concentrated. Purification by silica gel chromatography (100% dichloromethane→60% dichloromethane/ethyl acetate) gave the title compound (17 mg). MS 436.2 (M+1).

Provenance & Evidence