Sodium Bicarbonate → HCID 145726187, compound

Participants

Reaction Conditions

Reaction Steps

Titanium (IV) ethoxide (239 mg, 1.05 mmol) was added to a solution of tert-butyl [(6S,9R)-6-(2,3-difluorophenyl)-3-formyl-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]carbamate (205 mg, 0.524 mmol) and (R)-2-methylpropane-2-sulfinamide (79 mg, 0.655 mmol) in tetrahydrofuran (8 mL). The reaction mixture was heated to 60° C. After 6 h, the reaction mixture was allowed to cool to ambient temperature. Saturated sodium bicarbonate was added and the mixture was extracted with dichlormethane (3×). The organic extracts were dried with magnesium sulfate, filtered and concentrated. Purification by silica gel chromatography (100% dichloromethane→95% dichloromethane/methanol) gave the title compound (252 mg). MS 495.2 (M+1).

Provenance & Evidence