Triethylamine → HCID 59722587, compound

Participants

Reaction Steps

Triethylamine (7.0 μL, 0.05 mmol) was added to a solution of (6S,9R)-6-(2,3-difluorophenyl)-3-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-amine (17 mg, 0.05 mmol) and 4-nitrophenyl chloroformate (10.0 mg, 0.05 mmol) in tetrahydrofuran (3 mL) at 0° C. After 20 min, the hydrochloride salt of 3-piperidin-4-yl-1,3,4,5-tetrahydro-2H-1,3-benzodiazepin-2-one (14 mg, 0.05 mmol) and triethylamine (21 μL, 0.15 mmol) were added and the mixture allowed to warm to ambient temperature. After 1 h, saturated aqueous sodium carbonate was added and the mixture was extracted with dichloromethane (3×). The organic layer was washed with saturated brine, dried over magnesium sulfate, filtered and concentrated. Purification by silica gel chromatography (100% dichloromethane→93% dichloromethane/methanol) gave the title compound (22 mg). MS 617.2609 (M+1).

Provenance & Evidence