Methanol → HCID 67439246, compound

Participants

Reaction Conditions

Reaction Steps

Sulfuric acid (0.15 mL, 2.85 mmol) was added to a solution of tert-butyl [(6S,9R)-6-(2,6-difluorophenyl)-3-(1-hydroxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]carbamate (120 mg, 0.285 mmol) in methanol (1.5 mL). The reaction mixture was heated to 60° C. After 3 h, the reaction was quenched with saturated aqueous sodium bicarbonate. The mixture was extracted with dichloromethane (3×), washed with saturated brine, dried over magnesium sulfate, filtered and concentrated. MS 336.2 (M+1).

Provenance & Evidence