4-Chlorophenyl Isocyanate → HCID 178522070, compound

HRID 1664974Notes

Reaction equation

HRID 1664974 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([C:16]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=3[F:25])=[O:17])[CH2:12][CH2:11]2)[CH2:4][CH2:3]1.[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([N:33]=[C:34]=[O:35])=[CH:29][CH:28]=1>C(#N)C>[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([NH:33][C:34]([NH:1][C@H:2]2[CH2:7][CH2:6][C@H:5]([CH2:8][CH2:9][N:10]3[CH2:11][CH2:12][CH:13]([C:16](=[O:17])[C:18]4[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=4[F:25])[CH2:14][CH2:15]3)[CH2:4][CH2:3]2)=[O:35])=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 76934-Chlorophenyl IsocyanateHCID 178511516HCID 178511516, compound2×

Product 1

HCID 178522070HCID 178522070, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound was synthesized from Trans-{1-[2-(4-Amino-cyclohexyl)-ethyl]-piperidin-4-yl}-(2,4-difluoro-phenyl)-methanone (example 58, intermediate F) and 4-Chloro phenyl isocyanate in acetonitrile according to the procedure described for example 38. MS (m/e): 504.3 (M+H+).

Sources & evidence

ORD record
ord-ea22e820a7704886974147cc62ef1ea5
Source dataset
uspto-grants-2011_10
Patent number
US08039490B2

Reaction notes

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