4-Benzoylpiperidine hydrochloride → HCID 178453898, compound

HRID 1664983Notes

Reaction equation

HRID 1664983 reaction equation
Cl.[C:2]([CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:16]([O:20][C:21](=[O:32])[NH:22][C@H:23]1[CH2:28][CH2:27][C@H:26]([CH2:29][CH:30]=O)[CH2:25][CH2:24]1)([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21](=[O:32])[NH:22][C@H:23]1[CH2:24][CH2:25][C@H:26]([CH2:29][CH2:30][N:13]2[CH2:14][CH2:15][CH:10]([C:2](=[O:9])[C:3]3[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=3)[CH2:11][CH2:12]2)[CH2:27][CH2:28]1)([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 27244374-Benzoylpiperidine hydrochlorideHCID 178453924HCID 178453924, compound2×

Product 1

HCID 178453898HCID 178453898, compound

Procedure

From 4-benzoylpiperidine hydrochloride (200 mg) and [trans-4-(2-oxo-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester (intermediate C, 235 mg) by procedure A.2. Yield: 181 mg (49%). Off-white solid. MS (m/z): 415.3 ([M+H]+).

Sources & evidence

ORD record
ord-df8fc44e8af342e08f3d6f5fdc94ead2
Source dataset
uspto-grants-2011_10
Patent number
US08039490B2

Reaction notes

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