(3-Chloro-thiophen-2-yl)-piperidin-4-yl-methanone hydrochloride → HCID 178453904, compound

HRID 1664993Notes

Reaction equation

HRID 1664993 reaction equation
Cl.[Cl:2][C:3]1[CH:7]=[CH:6][S:5][C:4]=1[C:8]([CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)=[O:9].[C:16]([O:20][C:21](=[O:32])[NH:22][C@H:23]1[CH2:28][CH2:27][C@H:26]([CH2:29][CH:30]=O)[CH2:25][CH2:24]1)([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21](=[O:32])[NH:22][C@H:23]1[CH2:24][CH2:25][C@H:26]([CH2:29][CH2:30][N:13]2[CH2:14][CH2:15][CH:10]([C:8]([C:4]3[S:5][CH:6]=[CH:7][C:3]=3[Cl:2])=[O:9])[CH2:11][CH2:12]2)[CH2:27][CH2:28]1)([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 66627219(3-Chloro-thiophen-2-yl)-piperidin-4-yl-methanone hydrochlorideHCID 178453924HCID 178453924, compound2×

Product 1

HCID 178453904HCID 178453904, compound

Procedure

From (3-chloro-thiophen-2-yl)-piperidin-4-yl-methanone hydrochloride (100 mg) and [trans-4-(2-oxo-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester (intermediate C, 91 mg) by procedure A. 1. Yield: 85 mg (50%). White foam. MS (m/z): 455.3 ([M+H]+).

Sources & evidence

ORD record
ord-3907639b4b7c4165b23b2500b94e910b
Source dataset
uspto-grants-2011_10
Patent number
US08039490B2

Reaction notes

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