(3-Chloro-thiophen-2-yl)-piperidin-4-yl-methanone hydrochloride → HCID 178474969, compound

HRID 1664994Notes

Reaction equation

HRID 1664994 reaction equation
Cl.[Cl:2][C:3]1[CH:7]=[CH:6][S:5][C:4]=1[C:8]([CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)=[O:9].O=[CH:17][CH2:18][C@H:19]1[CH2:24][CH2:23][C@H:22]([NH:25][C:26](=[O:28])[CH3:27])[CH2:21][CH2:20]1>>[Cl:2][C:3]1[CH:7]=[CH:6][S:5][C:4]=1[C:8]([CH:10]1[CH2:15][CH2:14][N:13]([CH2:17][CH2:18][C@H:19]2[CH2:24][CH2:23][C@H:22]([NH:25][C:26](=[O:28])[CH3:27])[CH2:21][CH2:20]2)[CH2:12][CH2:11]1)=[O:9]

Participants

3

Reactant 2

HCID 66627219(3-Chloro-thiophen-2-yl)-piperidin-4-yl-methanone hydrochlorideHCID 178474986HCID 178474986, compound

Product 1

HCID 178474969HCID 178474969, compound

Procedure

From (3-chloro-thiophen-2-yl)-piperidin-4-yl-methanone hydrochloride (78 mg) and N-[trans-4-(2-oxo-ethyl)-cyclohexyl]-acetamide (54 mg, intermediate AG) by procedure A.1. Yield: 52 mg (45%). White solid. MS (m/z): 397.1 ([M+H]+).

Sources & evidence

ORD record
ord-e5f1bca2551743888c214e4d551e4ddc
Source dataset
uspto-grants-2011_10
Patent number
US08039490B2

Reaction notes

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