(5-Chloro-thiophen-2-yl)-piperidin-4-yl-methanone hydrochloride → HCID 178453901, compound

HRID 1664997Notes

Reaction equation

HRID 1664997 reaction equation
Cl.[Cl:2][C:3]1[S:7][C:6]([C:8]([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])=[CH:5][CH:4]=1.[C:16]([O:20][C:21](=[O:32])[NH:22][C@H:23]1[CH2:28][CH2:27][C@H:26]([CH2:29][CH:30]=O)[CH2:25][CH2:24]1)([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21](=[O:32])[NH:22][C@H:23]1[CH2:24][CH2:25][C@H:26]([CH2:29][CH2:30][N:13]2[CH2:14][CH2:15][CH:10]([C:8]([C:6]3[S:7][C:3]([Cl:2])=[CH:4][CH:5]=3)=[O:9])[CH2:11][CH2:12]2)[CH2:27][CH2:28]1)([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 66625802(5-Chloro-thiophen-2-yl)-piperidin-4-yl-methanone hydrochlorideHCID 178453924HCID 178453924, compound2×

Product 1

HCID 178453901HCID 178453901, compound

Procedure

From (5-chloro-thiophen-2-yl)-piperidin-4-yl-methanone hydrochloride (585 mg) and [trans-4-(2-oxo-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester (intermediate C, 530 mg) by procedure A.2. Yield: 513 mg (51%). Light yellow solid. MS (m/z): 455.2 ([M+H]+).

Sources & evidence

ORD record
ord-2a4afb6a38204cd09cc9e999ea58ce83
Source dataset
uspto-grants-2011_10
Patent number
US08039490B2

Reaction notes

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