HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorobenzenesulphonyl chloride → N-(5-bromo-thiophen-2-ylmethyl)-3-chloro-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorobenzenesulphonyl chloride | HCID 17909 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (5-Bromothiophen-2-yl)methanamine | HCID 23130577 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(5-bromo-thiophen-2-ylmethyl)-3-chloro-benzenesulfonamide | HCID 35408893 | — |
Reaction Steps
In analogy to example 4, step 1, 1-(5-bromo-2-thienyl)methanamine was reacted with 3-chlorobenzenesulfonyl chloride and N,N-diisopropyl ethyl amine in dichloromethane to give N-(5-bromo-thiophen-2-ylmethyl)-3-chloro-benzenesulfonamide as a colorless solid. MS: 363.9 ([M−H]−)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039493B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-56badee85d834d08b71575581cd23efe |
| Source note | uspto-grants-2011_10 |