HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzenesulfonyl chloride → N-(2-bromo-thiazol-5-ylmethyl)-2-chloro-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzenesulfonyl chloride | HCID 76187 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | c-(2-Bromo-thiazol-5-yl)-methylamine hydrochloride | HCID 71434973 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(2-bromo-thiazol-5-ylmethyl)-2-chloro-benzenesulfonamide | HCID 67441135 | — |
Reaction Steps
In analogy to example 1, step 1, 2-bromo-5-aminomethyl-thiazole hydrochloride was reacted with 2-chlorobenzenesulfonylchloride and N,N-diisopropyl ethyl amine in dichloromethane to give N-(2-bromo-thiazol-5-ylmethyl)-2-chloro-benzenesulfonamide as an off-white solid. MS: 367.0 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039493B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-7059e3810b764eb084d30660e5b914c0 |
| Source note | uspto-grants-2011_10 |