Water → HCID 67438423, compound

Participants

Reaction Steps

To a stirred solution of the crude (5-bromo-furan-2-ylmethyl)-isobutyl-amine from step 1 (686 mg) in dichloromethane (8 mL) were added N,N-diisopropyl ethyl amine (686 mg) and 2-chlorobenzenesulfonylchloride (458 mg). The mixture was stirred for 18 h at r.t. Water was added and the mixture was extracted with dichloromethane. The organic phase was dried (MgSO4), filtered and concentrated under reduced pressure. The product was purified by chromatography (SiO2, cyclohexane/ethyl acetate 4:2) to give N-(5-bromo-furan-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide (1.2 g) as a colorless oil.

Provenance & Evidence