HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzenesulfonyl chloride → N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzenesulfonyl chloride | HCID 76187 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | [(4-Bromothiophen-2-yl)methyl](2-methylpropyl)amine | HCID 28833175 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide | HCID 67439155 | — |
Reaction Steps
In analogy to example 13, step 2, (4-bromo-thiophen-2-ylmethyl)-isobutyl-amine was reacted with 2-chlorobenzenesulfonylchloride in presence of N,N-diisopropyl ethyl amine in dichloromethane to give N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039493B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-08e901e300cb46c0a20f0af16c99040d |
| Source note | uspto-grants-2011_10 |