HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → Isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-(Methylsulfonyl)phenylboronic acid | HCID 2773542 | — |
| Reactant | N-[(5-Bromothiophen-2-yl)methyl]-2-methylpropan-1-amine | HCID 28428595 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | Isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine | HCID 67441398 | — |
Reaction Steps
In analogy to example 1, step 3, (5-bromo-thiophen-2-ylmethyl)-isobutyl-amine was reacted with (3-methylsulfonylphenyl)-boronic acid, Na2CO3 and dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct in dioxane/water to give isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine as a light yellow oil. MS: 324.3 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039493B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-27e3082b015047ce8608dce4bb77cd16 |
| Source note | uspto-grants-2011_10 |