HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → N-isobutyl-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine | HCID 67441398 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-isobutyl-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-methanesulfonamide | HCID 25234391 | — |
Reaction Steps
In analogy to example 13, step 2, isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine was reacted with methanesulfonyl chloride in presence of N,N-diisopropyl ethyl amine in dichloromethane to give N-isobutyl-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-methanesulfonamide as a colorless solid. MS: 419.3 ([M+NH4]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039493B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-4cf62d17487c4a109e7fc2aa5c817451 |
| Source note | uspto-grants-2011_10 |